Halobacterium salinarum, et pulveres in mole NMN AASraw facit?

Allopregnanolone

Rating: Category:

Allopregnanolone, also known as Sepranolone et Isopregnanolone, est moleculas modulantes GABA receptor ac parem genus vulgare betahydroxysteroid XI-I (11β, HSD1) ...

depictio producti

basic proprietates

Product # Allopregnanolone
Number CAS 516, 55 2,
Molecular Formula C21H34O2
Pondus formulae 318.5
definition NSC, (XCVII)LXXVIII; U-CMXLIX, UC-MX; NSC97078; U0949; UC1010; NSC (XCVII)LXXVIII; U CMXLIX, UC MX; Isopregnanolone; Allopregnanolon; Sepranolone; 97078-0949-1010; -XX-unum-of-97078beta 0949alpha Pregnan,
aspectus album pulveris
Tractantem et repono Siccum, et in tenebris 0 - C pro brevis terminus IV (hebdomades dierum ad) -4 C non est diu terminum (in mensibus anni.)

 

Allopregnanolone Description

Allopregnanolone, also known as Sepranolone et Isopregnanolone, est moleculas modulantes GABA receptor ac parem genus vulgare betahydroxysteroid XI-I (11β, HSD1). Sepranolone neurological compositis potens est, naturaliter fit in intellectu et corpore, ut effectus ex modulatur ipsa? Allopregnanolone (ALLO). ALLO est potentior neurosteroid implicantur stress- et metum comparare-related condiciones vndique a Tourette ut OCD, PTSD, coactioni obnoxiae alea, PROCLIVITAS, PMDD, CEPHALEA Menstruus.

 

Vitro Allopregnanolone

M. interactiones

Allopregnanolone pregnane neurosteroid machinationem inhibendi ius est endogenous. Facta est de progesterone, et allosteric est modulator positivum actio ad in-γ aminobutyric GABA () receptor in Gabaa. Allopregnanolone est similis effectus qui ex aliis positivum allosteric modulators GABA in Gabaa receptor actio est ut benzodiazepines, inter anxiolytic, leniendo, et anticonvulsant actio. Tota denique-tuning de allopregnanolone produci Endogenously Neurophysiological partes in Gabaa modularetur et receptor actio ex pluribus positivum allosteric modulators agonists in Gabaa et receptor.

Aeque certa est modulator amet agit Allopregnanolone allosteric receptor Gabaa. Allopregnanolone vero, qui aliis neurosteroids THDOC inhibendi, positive modulatur omni colle Isoforms receptor qui summam exhibent Rata subunits δ Isoforms continens. Allopregnanolone inventus est etiam agere sicut positivum allosteric modulator de Gabaa ρ-receptor actio quamquam effectus huius lateat. Insuper de suis actibus GABA receptores, allopregnanolone, sicut progesterone, quod nota esse negans est modulator allosteric Nach receptores, et quasi negans agendum videtur de allosteric modulator HT5 V-receptor. Una cum aliis machinationem inhibendi ius neurosteroids, nulla actio vel ad modicum allopregnanolone appareat esse tunc, gatum ligand alius channels Ion, inter quas Electrofisiología, AMPA, kainate et glycine receptoribus.

 

antidepressant effectus,

Mechanism de qua neurosteroid Gabaa quasi receptor PAMS brexanolone est antidepressant effectus est ignotum. Alia receptor PAMS Gabaa ut benzodiazepines nonne vis probari non cogitari antidepressants et tamen praescriptis clinicians Cialis tristitia praeteritum. Neurosteroid receptor PAMS Gabaa, ut penitus nota Gabaa sub-populatio receptores, & aliter quam benzodiazepines. Ut exempla Gabaa receptor potentiating neurosteroids preferentially ut target-δ precursor receptorum continentur in Gabaa, atque augendae tam tonic et mediatae inhibicionis phasic receptores juxta Gabaa. Est etiam possibile quod potest agere in aliud allopregnanolone neurosteroids quasi scuta, inter membranam receptores, progesterone, gatum calcium-T-voltage genus rivos ejus, et aliis, antidepressant effectus ad mediationem adhibitis.

 

Application Allopregnanolone

Allopregnanolone est naturaliter produci in prima moleculas acts ut cerebrum. Ut medicamento est quod venundatus sub notam nomen Zulresso et facies ad postpartum tristitia. Est usus in a infunduntur a vein super LX-hora tempus sub medicinae vigilantia.

Allopregnanolone ex parte effectus potest includere sedation, a somno, arida os, calidum fulguris, et lipothymia. Neurosteroid est modulator et acts ut a positive allosteric de Gabaa receptor-γ neurotransmitter inhibendi ius est major Class of target aminobutyric GABA ().

Quia probatus est Allopregnanolone usu medicorum in Civitatibus Foederatis Americae 2019. Quod per US Cibus et medicamentis Administration (FDA) considers it to be a primo-in-genus elit. Quod longo tempore administratione, cum sumptus atque curatio tempore, in unum, non multos erexit accessibility curam de mulieribus.

 

Reference

[I] Lionetto L. De Andreas F, M solitavisse noctis, Curto M, D Sabato, Simmaco M: P Bossu, Sacchinelli E, Orfei MD, Piras F, N Banaj, G. Spalletta LC-MS / analysis of MS simultaneous allopregnanolone, epiallopregnanolone, pregnanolone, dehydroepiandrosterone et dehydroepiandrosterone III-plasma sulfate in homine. Bioanalysis. Mar MMXVII: IX (VI) 1-3. doi: 2017 / bio-9-6. PubMed PMID: 527.

[II] Horishita T, Yanagihara N, S Ueno, Sudo ego, ego Uezono, Okura D, Minami T, T Kawasaki, Sata T. Neurosteroids allopregnanolone sulfate et pregnanolone sulfate habent diversos effectus, ex in α precursor neuronal-voltage gatum sodium Nav2 canales, Nav1.2, Nav1.6 et Homo oocytes Nav1.7 exprimuntur. Anesthesiology. Sep MMXIV, CXXI ​​(III): 1.8-2014. Doi, 121 / ALN.3. PubMed PMID: 620.

[III] Zorumski CF acquales funt, SP Pauli, Covey DF, eft S Mennerick (November MMXIX). "Neurosteroids antidepressants, et quod nova anxiolytics: A, & receptores, & ultra GABA". Neurobiology lacus. XI: 3. doi: 2019 / j.ynstr.11. PMC 100196. PMID 10.1016.

[IV] Warner, MD; Peabody, CA; Whiteford, EA; Hollister, LE (April MCMLXXXVIII). "Alprazolam quasi antidepressant". Quod Acta Fusce Psychiatry. XLIX (IV) 4-1988. ISSN 49-4. PMID (MMMCCLXXXI)CMXXXI.

[V] Srisurapanont, M .; Boonyanaruthee: V. (MCMXCVII). Alprazolam ad antidepressants et vexillum treatment of exanimationes incidamus: a meta-analysis de antidepressant effectus. Et Centrum enim Recensiones Dissemination (UK). PMID 5.

[VI] Reddy DS (MMX). Neurosteroids: endogenous humani cerebri partes ac medicinales potentiae. Prog. Res cerebrum. Research profectum apparet ingenium. 6, pp. 2010-186. doi: 113 / B37-10.1016-978-0-444-53630. ISBN 3.00008. PMC 7. PMID 9780444536303.

[VII] offeres vitulum autem ipfarum AE, AL Clark, Grady, SR, Robinson SF, Slobe BS, M marcas, et al. (June MCMXCVII). "Inflectere Neurosteroids nicotinic receptor striatal mus munus quod in thalamic synaptosomes". Journal de neurochemistry. LXVIII (VI): 7-1997. doi: 68 / j.6-2412.x. PMID 23.

[VIII] Slavíková B; J Bujons, Matyas L, M Vidal, Babot Z, Z Krištofíková, Suñol C, C circulum Kasal A. Allopregnanolone et pregnanolone analoga pluries prius ostensa sunt: ​​componendo et operatio. Res J med. Mar MMXIII XXVIII: LVI (VI): 8-2013. doi: 28 / jm56. PubMed PMID: 6.