N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder Est piperazinyl phenyl urea cuius structuram differt a alkyl carbamates et alpha-keto heterocyclic suis Revolutionibus componit et potens et electionem selectivam Matrix pingue acidum amide hydrolase (FAAH) (IC50s = 34 et 33 NM in rat et humani respective?) id est possit in transire sanguine cerebrum barrier.1 20 mg / kg, covalently obligat ad active locus FAAH aniline per FISSIO generating functionality de urea et FAAH, poperazinyl carbamate.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136, 29 8,
Quod puritas: ≥99% (silicium)
Synonym: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Molecular Weight: 365.459
Liquescens punctum: 240.48
Ferveret: 559.69 ° C ad 760 mmHg
density: 1.3 ~ g / cm3
PRAECLUSIO nativitate: 4 copia ad F +
solubility: DMSO: ≥28mg / ml
Refractivam index: n20D 1.68
Color: Solidum crystallina
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
Key InChI: BHBOSTKQCZEAJM UHFFFAOYSA-N,


II. Phenyl-N-4- (3, phenyl, 1,2,4, thiadiazol 5-y-) 1-piperazine-Powder carboxamid exolvuntur sunt in usus,

1.Name:

-N-phenyl 4- (3, phenyl, 1,2,4, thiadiazol 5-y-) 1-piperazine-carboxamid pulveris, jnj pulverem 166101

2.How-N enim est opus in phenyl, 4- (3, phenyl, 1,2,4, thiadiazol 5-y-) 1-piperazine-Powder carboxamid usus?

FAAH preincubated cum JNJ1661010, quasi reversibility tardus autem ad mutuam JNJ1661010 activae et locum, quo altior est: accelerated ad temperaturis. Jnj, 1661010 est covalent, mechanism fundatur in subiecto, sicut Matrix, examini subiciantur, LC-ESI MS. Jnj, 1661010 docks cum phenylthiadiazole in hydrophobic cuniculum complesset, et phenylurea in hydrophilic sinum autem FAAH, jnj, 1661010 (20 mg / kg IP) vetat obscura FAAH a certe 85% enim ad 4 h post dosing, unde cumulus lipidorum ethanolamides in cerebrum rat. Jnj 1661010, consectetuer vel adversas adhaereret cum tangentes allodynia maximam efficaciam ad 90 circa 30% min postdose in utroque mitis thermal iniuriam (MTI) rat habebat mures aureos et exemplar. Jnj, 1661010 (20 mg / kg) a cladibus ad tangendi allodynia 60.8% min ad 30 rat spinalis ligation in exemplum injuriam. Jnj, 1661010 (50 mg / kg IP) ostendit a significant ADTENUATIO exemplar carrageenan rat de hyperalgesia ad 30 min in postdose non filii dolor dolor.
Cum jnj-carborundum dosed 1661010 (20 mg / kg IP) Cmax habet plasma ex 26.9 μM ad Tmax 0.75 ex h et Cmax ad cerebrum ex 6.04 μM Tmax de 2 ad h. Jnj, 1661010 (20 mg / kg IP) nia in cerebrum TEXTUS in cerebri FAAH et elevat AEA gradu rat.

3.Warning N-in-phenyl 4- (3, phenyl, 1,2,4, thiadiazol-y-5) carboxamid pulveris-piperazine-1

4.Further instructiones:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Ut 10grams min.
Duis Inquisitio super numerum (Infra 1kg) 12 mitti in horas pretium.
Nam quo maior (Within 1kg) potest esse misit in 3 workingdays iuxta mercedem.

6. Phenyl-N-4- (3, phenyl, 1,2,4, thiadiazol 5-y-) 1-piperazine-Powder carboxamid Recipes:

Ad nostrae inquisitionis Customer representitive (CSR) pro details, quia referat.

7. -N-phenyl 4- (3, phenyl, 1,2,4, thiadiazol 5-y-) carboxamid pulveris-piperazine-1 Marketing:

Ut praeberi ventura sunt in futurum.


III. Phenyl-N-4- (3, phenyl, 1,2,4, thiadiazol 5-y-) sciureus pulveris-piperazine-1 HNMR

Nos Aprepitant pulveris et supplemento se, Aprepitant pulveris pro sale, Cruda Aprepitant pulveris (170729, 80, 3) hplc≥98% | AASraw R & D Reagents


IV. Quam ad buy-N-phenyl 4- (3, phenyl, 1,2,4, thiadiazol 5-y-) sciureus pulveris-piperazine-1 ex AASraw?

1.To contact us a nobis inscriptioratio inquisitionis vel online circomos muneris repraesentativum (CSR).
Oratio tua nobis 2.To perquirerent quantitatem.
3.Our CSR providebit vos cum quotation: terminum solucionis, tracking numero, quod partum via aestimatur diem adventus (ETA).
Acta res in 4 12.Payment mittetur (cf. infra 10kg ordo).
Et accepit 5.Goods comment.


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